Technology Process of N-[(3S,4R)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-2-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-acetamide
There total 9 articles about N-[(3S,4R)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-2-oxo-7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaH / dimethylformamide / Ambient temperature
2: SnCl2*2H2O, conc. HCl / methanol / 4.5 h
3: CH3ONa / methanol / 3 h / Heating
4: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min
5: 1.) LiI, H2O, 2.) pyridine / 1.) pyridine, reflux, 1.5 h, 2.) RT, 24 h
6: KHCO3 / butan-2-one
7: NaN3, Bu4NHSO4 / dimethylformamide / 90 °C
8: H2, CF3COOH / Pd/C
9: pyridine / dimethylformamide
With
pyridine; hydrogenchloride; sodium azide; water; hydrogen; oxygen; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium hexamethylsilazane; sodium hydride; potassium hydrogencarbonate; trifluoroacetic acid; tin(ll) chloride; lithium iodide; phosphorous acid trimethyl ester;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00082a020
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaH / dimethylformamide / Ambient temperature
2: SnCl2*2H2O, conc. HCl / methanol / 4.5 h
3: CH3ONa / methanol / 3 h / Heating
4: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min
5: 1.) LiI, H2O, 2.) pyridine / 1.) pyridine, reflux, 1.5 h, 2.) RT, 24 h
6: KHCO3 / butan-2-one
7: NaN3, Bu4NHSO4 / dimethylformamide / 90 °C
8: H2, CF3COOH / Pd/C
9: pyridine / dimethylformamide
With
pyridine; hydrogenchloride; sodium azide; water; hydrogen; oxygen; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium hexamethylsilazane; sodium hydride; potassium hydrogencarbonate; trifluoroacetic acid; tin(ll) chloride; lithium iodide; phosphorous acid trimethyl ester;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00082a020
- Guidance literature:
-
Multi-step reaction with 7 steps
1: CH3ONa / methanol / 3 h / Heating
2: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min
3: 1.) LiI, H2O, 2.) pyridine / 1.) pyridine, reflux, 1.5 h, 2.) RT, 24 h
4: KHCO3 / butan-2-one
5: NaN3, Bu4NHSO4 / dimethylformamide / 90 °C
6: H2, CF3COOH / Pd/C
7: pyridine / dimethylformamide
With
pyridine; sodium azide; water; hydrogen; oxygen; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium hexamethylsilazane; potassium hydrogencarbonate; trifluoroacetic acid; lithium iodide; phosphorous acid trimethyl ester;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00082a020
