(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

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Chemical Name:(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate
CAS No.:1240522-74-0
Molecular Formula:C₂₁H₂₃N₅O₃
Molecular Weight:393.445
Hs Code.:

Synonyms:(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

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Chemical Property of (S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

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Technology Process of (S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

There total 4 articles about (S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1240522-73-9
(S)-ethyl 2-(5-(2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

: 1240522-74-0
(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

Guidance literature:: (S)-ethyl 2-(5-(2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate; With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 12h;

With water; In dichloromethane;

Reference yield:

: C₂₆H₃₁N₅O₅*C₂HF₃O₂

: 1240522-74-0
(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ml4000854

Reference yield:

: 1240522-72-8
ethyl 2-(5-amino-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

: 1240522-74-0
(S)-ethyl 2-(5-(2-amino-3-phenylpropanamido)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C

1.2: HPLC columh / 0.75 h

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000854