ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

Base Information

Chemical Name:ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride
CAS No.:1449242-14-1
Molecular Formula:C₁₆H₂₁N₃O₂*ClH
Molecular Weight:323.823
Hs Code.:

Synonyms:ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

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Technology Process of ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

There total 4 articles about ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1449242-11-8
ethyl 2-amino-6-methyl-4-(2-phenethyl)-1,4-dihydropyrimidine-5-carboxylate

: 1449242-14-1
ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;
DOI:10.1016/j.tet.2013.04.127

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1449242-14-1
ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride / 3 h / 120 °C / Sealed tube

2.1: methyl trifluoromethanesulfonate / chlorobenzene / 3.5 h / 0 - 20 °C

2.2: 17 h / 95 - 100 °C / Sealed tube

3.1: hydrogenchloride / methanol; 1,4-dioxane / 20 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; methyl trifluoromethanesulfonate; In 1,4-dioxane; methanol; chlorobenzene;
DOI:10.1016/j.tet.2013.04.127

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1449242-14-1
ethyl 2-imino-6-methyl-4-(2-phenethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride / 3 h / 120 °C / Sealed tube

2.1: methyl trifluoromethanesulfonate / chlorobenzene / 3.5 h / 0 - 20 °C

2.2: 17 h / 95 - 100 °C / Sealed tube

3.1: hydrogenchloride / methanol; 1,4-dioxane / 20 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; methyl trifluoromethanesulfonate; In 1,4-dioxane; methanol; chlorobenzene;
DOI:10.1016/j.tet.2013.04.127