7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 1446946-30-0
• Molecular Formula: C₂₇H₂₉FN₄O₆
• Molecular Weight: 524.549
• Mol file: 1446946-30-0.mol

Synonyms:7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property of 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 8 articles about 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate (139693-52-0) + 3-amino-4-(2'-methoxylbenzyloxyimino)piperidine dihydrochloride → 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1446946-30-0)

Guidance literature:

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate; 3-amino-4-(2'-methoxylbenzyloxyimino)piperidine dihydrochloride; With triethylamine; In acetonitrile; at 20 - 50 ℃;

With sodium hydroxide; In acetonitrile; at 50 ℃; for 1h;

DOI:10.3390/molecules18043872

Reference yield:

C19H27N3O5 (1446946-04-8) → 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1446946-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hypobromide / acetonitrile / 11 h / 5 - 20 °C

2.1: hydrogenchloride / dichloromethane / 1.5 h / 20 °C

3.1: triethylamine / acetonitrile / 20 - 50 °C

3.2: 1 h / 50 °C

With hydrogenchloride; sodium hypobromide; triethylamine; In dichloromethane; acetonitrile; 1.1: |Hofmann Rearrangement;

DOI:10.3390/molecules18043872

Reference yield:

C18H27N3O4 (1446946-17-3) → 7-[3-amino-4-(2'-methoxybenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1446946-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane / 1.5 h / 20 °C

2.1: triethylamine / acetonitrile / 20 - 50 °C

2.2: 1 h / 50 °C

With hydrogenchloride; triethylamine; In dichloromethane; acetonitrile;

DOI:10.3390/molecules18043872

upstream raw materials:

C₁₉H₂₇N₃O₅

C₁₈H₂₇N₃O₄

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate