C₁₆H₁₇N₅O

Base Information

• Chemical Name: C₁₆H₁₇N₅O
• CAS No.: 1353858-11-3
• Molecular Formula: C₁₆H₁₇N₅O
• Molecular Weight: 295.344
• Mol file: 1353858-11-3.mol

Synonyms:C₁₆H₁₇N₅O

Chemical Property of C₁₆H₁₇N₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₇N₅O

There total 3 articles about C₁₆H₁₇N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-amino-5-hydroxymethylphenyl)methanol (71176-54-0) → C16H17N5O (1353858-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With pyridine; thionyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1139/v11-133

Reference yield:

5-aminoisophthalic acid (99-31-0) → C16H17N5O (1353858-11-3)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 0 °C / Inert atmosphere; Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With pyridine; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1139/v11-133

Reference yield:

diethyl 5-aminoisophthalate (42122-73-6) → C16H17N5O (1353858-11-3)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With pyridine; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1139/v11-133

upstream raw materials:

5-aminoisophthalic acid

diethyl 5-aminoisophthalate

(3-amino-5-hydroxymethylphenyl)methanol

Downstream raw materials:

3,5-bis((1H-pyrazol-1-yl)methyl)aniline

4-(3,5-bis((1H-pyrazol-1-yl) methyl)phenylamino)-4-oxobutanoic acid