5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Base Information

Chemical Name:5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one
CAS No.:1408087-46-6
Molecular Formula:C₂₂H₁₄F₃N₅O₂
Molecular Weight:437.381
Hs Code.:

Synonyms:5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Property of 5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

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Technology Process of 5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

There total 15 articles about 5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1408088-03-8
(S)/(R)-2-(1-aminoethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

: 1651-29-2
6-chloro-2-fluoropurine

: 1408087-46-6
5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; for 248h; Reflux;

Reference yield:

: 146137-74-8
2-fluoro-6-methoxybenzaldehyde

: 1408087-46-6
5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: diethyl ether / 12 h / 20 °C / Cooling with ice

1.2: 0 °C

2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice

4.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

5.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

5.3: 12 h / Reflux

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 12 h

10.1: hydrazine hydrate / methanol / 3 h / Reflux

11.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 248 h / Reflux

With pyridine; aluminum (III) chloride; N-Bromosuccinimide; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 456-49-5
1-fluoro-3-methoxybenzene

: 1408087-46-6
5-fluoro-2-(1-(2-fluoro-9H-purin-6-ylamino)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h

2.1: diethyl ether / 12 h / 20 °C / Cooling with ice

2.2: 0 °C

3.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice

5.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

6.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

6.3: 12 h / Reflux

7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

9.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 12 h

11.1: hydrazine hydrate / methanol / 3 h / Reflux

12.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 248 h / Reflux

With pyridine; aluminum (III) chloride; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; hydrazine hydrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;