1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione

Base Information

• Chemical Name: 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione
• CAS No.: 108463-14-5
• Molecular Formula: C₂₁H₁₉ClO₄
• Molecular Weight: 370.832
• Mol file: 108463-14-5.mol

Synonyms:1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione

Chemical Property of 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione

There total 2 articles about 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-acetyl-1-tetralone (17216-08-9) + ethyl 2,5-dichlorobenzoate (35112-27-7) → 1-(2,5-Dichlorophenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione (108463-13-4) + 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione (108463-14-5)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 6h; Heating;

DOI:10.1002/jhet.5570230452

Reference yield:

2-acetyl-1-tetralone (17216-08-9) + methyl 5-chloro-2-ethoxybenzoate (75230-37-4) → 1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione (108463-14-5)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 6h; Heating;

DOI:10.3987/COM-88-4577

Reference yield: 88.0%

1-(5-Chloro-2-ethoxyphenyl)-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-1,3-propanedione (108463-14-5) → 2-(5-Chloro-2-ethoxyphenyl)-5,6-dihydro-4H-naphtho<1,2-b>pyran-4-one (108463-25-8)

Guidance literature:

With sulfuric acid; at 0 ℃; for 0.666667h;

DOI:10.1002/jhet.5570230452

upstream raw materials:

2-acetyl-1-tetralone

ethyl 2,5-dichlorobenzoate

methyl 5-chloro-2-ethoxybenzoate

Downstream raw materials:

2-(5-Chloro-2-ethoxyphenyl)-5,6-dihydro-4H-naphtho<1,2-b>pyran-4-one