Technology Process of 4-((2,4-dichlorophenyl)methoxy)-1-(9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridin-2-yl)pyridin-2(1H)-one
There total 7 articles about 4-((2,4-dichlorophenyl)methoxy)-1-(9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridin-2-yl)pyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2,4-dichlorobenzyloxy)pyridin-2(1H)-one; tert-butyl 2-bromo-9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate;
With
copper(l) iodide; 8-quinolinol; caesium carbonate;
In
dimethyl sulfoxide;
at 135 ℃;
for 16h;
Inert atmosphere;
With
ammonium hydroxide; water;
In
methanol; dichloromethane; dimethyl sulfoxide;
at 25 ℃;
for 0.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrazine / 0.5 h / 70 °C
2.1: methanol / 2 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.33 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C
4.1: toluene-4-sulfonic acid / 1.5 h / 160 °C
4.2: 2 h / 20 °C
5.1: caesium carbonate; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 16 h / 135 °C / Inert atmosphere
5.2: 0.5 h / 25 °C / Inert atmosphere
With
copper(l) iodide; 8-quinolinol; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; hydrazine;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / toluene / 18 h / 105 °C / Inert atmosphere
2.1: formic acid; ammonium acetate / water / 96 h / Reflux
3.1: caesium carbonate; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 16 h / 135 °C / Inert atmosphere
3.2: 0.5 h / 25 °C / Inert atmosphere
With
copper(l) iodide; 8-quinolinol; formic acid; 1,10-Phenanthroline; ammonium acetate; caesium carbonate;
In
water; dimethyl sulfoxide; toluene;
