2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

Base Information

Chemical Name:2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile
CAS No.:1373353-56-0
Molecular Formula:C₁₉H₁₆BrN₃
Molecular Weight:366.26
Hs Code.:

Synonyms:2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

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Chemical Property of 2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

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Technology Process of 2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

There total 2 articles about 2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 87-52-5
3-(Dimethylaminomethyl)indole

: 1373353-49-1
2-[(E)-(4-bromobenzylidene)amino]propanenitrile

: 1373353-56-0
2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

Guidance literature:: With tributylphosphine; In acetonitrile; at 140 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1055/s-0031-1289675

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1373353-56-0
2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate; acetic acid / dichloromethane / 20 °C / Inert atmosphere

2: tributylphosphine / acetonitrile / 1 h / 140 °C / Microwave irradiation; Inert atmosphere

With tributylphosphine; magnesium sulfate; acetic acid; In dichloromethane; acetonitrile;
DOI:10.1055/s-0031-1289675

Reference yield: 81.0%

: 1373353-56-0
2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile

: 1373353-60-6
1-(4-bromophenyl)-3-methyl-9H-β-carboline

Guidance literature:: 2-[(E)-(4-bromobenzylidene)amino]-3-(1H-indol-3-yl)-2-methylpropanenitrile; With trifluoroacetic acid; In dichloromethane; at 60 ℃; for 0.166667h; Molecular sieve; Microwave irradiation; Inert atmosphere;

With iodine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0031-1289675