4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one

Base Information

Chemical Name:4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one
CAS No.:68726-79-4
Molecular Formula:C₁₂H₈O₄
Molecular Weight:216.193
Hs Code.:
DSSTox Substance ID:DTXSID101264632

Synonyms:68726-79-4;DTXSID101264632;4,9-Dihydroxynaphtho[2,3-c]furan-1(3H)-one

Suppliers and Price of 4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:216.04225873
Heavy Atom Count:16
Complexity:303

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2=C(C3=CC=CC=C3C(=C2C(=O)O1)O)O

Technology Process of 4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one

There total 1 articles about 4,9-dihydroxy-1H-benzo[f][2]benzofuran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 61260-15-9
dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate

: 497-23-4
2-buten-4-olide

: 68726-79-4
4,9-dihydroxynaphtho<2,3-c>furan-1(3H)-one

Guidance literature:: dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate; With lithium tert-butoxide; In tetrahydrofuran;

2-buten-4-olide; Further stages.;
DOI:10.1021/ol006531+

Reference yield:

: 68726-79-4
4,9-dihydroxynaphtho<2,3-c>furan-1(3H)-one

: 308277-85-2
(9-benzyloxy-4-methoxy-1,3-dihydro-naphtho[2,3-c]furan-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / K₂CO₃ / acetone / 8 h / Heating

2.1: 79 percent / B-iodo-9-BBN / CH₂Cl₂; various solvent(s) / 18 h / Heating

3.1: 98 percent / K₂CO₃ / acetone / 12 h / Heating

4.1: LDA / tetrahydrofuran; various solvent(s) / 0.75 h / -78 °C

4.2: tetrahydrofuran; various solvent(s) / -78 - 0 °C

5.1: 1.98 g / triethylsilane; TFA / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; potassium carbonate; B-iodo-9-BBN; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone; 1.1: Methylation / 2.1: Substitution / 3.1: Alkylation / 4.1: Metallation / 4.2: Substitution / 5.1: Substitution;
DOI:10.1021/ol006531+

Reference yield:

: 68726-79-4
4,9-dihydroxynaphtho<2,3-c>furan-1(3H)-one

: 1026372-60-0
(9-benzyloxy-1-hydroxy-4-methoxy-1,3-dihydro-naphtho[2,3-c]furan-1-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / K₂CO₃ / acetone / 8 h / Heating

2.1: 79 percent / B-iodo-9-BBN / CH₂Cl₂; various solvent(s) / 18 h / Heating

3.1: 98 percent / K₂CO₃ / acetone / 12 h / Heating

4.1: LDA / tetrahydrofuran; various solvent(s) / 0.75 h / -78 °C

4.2: tetrahydrofuran; various solvent(s) / -78 - 0 °C

With potassium carbonate; B-iodo-9-BBN; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone; 1.1: Methylation / 2.1: Substitution / 3.1: Alkylation / 4.1: Metallation / 4.2: Substitution;
DOI:10.1021/ol006531+