3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

Base Information

Chemical Name:3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester
CAS No.:87870-82-4
Molecular Formula:C₂₁H₂₇NO₅Se
Molecular Weight:452.409
Hs Code.:

Synonyms:3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

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Chemical Property of 3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

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Technology Process of 3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

There total 7 articles about 3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 645-96-5
Benzeneselenol

: 87870-81-3
3-((1S,2R,3S,5S)-1-Acetoxymethyl-3-cyanomethyl-2-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)-propionic acid methyl ester

: 87870-82-4
3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 ℃; for 7h;
DOI:10.1021/ja00364a043

Reference yield:

: 87935-56-6
3-((1R,5R)-5-Cyanomethyl-1,2-dimethyl-cyclopent-2-enyl)-propionic acid methyl ester

: 87870-82-4
3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SeO₂ / acetic acid / 20 h / 140 - 143 °C

2: 15.2 g / MCPBA / CH₂Cl₂

3: 55 percent / i-Pr₂NEt / dimethylformamide / 7 h / 70 °C

With selenium(IV) oxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00364a043

Reference yield:

: 1195671-92-1
(+)-8-bromocamphor

: 87870-82-4
3-((1R,2S,3R,5S)-2-Acetoxymethyl-5-cyanomethyl-2-hydroxy-1-methyl-3-phenylselanyl-cyclopentyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: KI / dimethylformamide / 110 °C

2: 76 percent / 1.) KH, 3.) KI / 1.) Et₂O, reflux, 2 h, 2.) DMF, 120 deg C, 40 h, 3.) 140 deg C, 64 h

3: 67 percent / NH₂OH*HCl / pyridine / 24 h / Ambient temperature

4: 1.) (CF₃CO)2O, 2.) TFA / 1.) CH₂Cl₂, 0 deg C, 4 h, 2.) RT, 24 h

5: SeO₂ / acetic acid / 20 h / 140 - 143 °C

6: 15.2 g / MCPBA / CH₂Cl₂

7: 55 percent / i-Pr₂NEt / dimethylformamide / 7 h / 70 °C

With selenium(IV) oxide; hydroxylamine hydrochloride; potassium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trifluoroacetic anhydride; potassium iodide; In pyridine; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00364a043