3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

Base Information

• Chemical Name: 3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one
• CAS No.: 882041-72-7
• Molecular Formula: C₃₄H₃₀O₉
• Molecular Weight: 582.607
• Mol file: 882041-72-7.mol

Synonyms:3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

Chemical Property of 3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

There total 1 articles about 3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 2-(benzo[1,3]dioxol-5-yl)-1-(4-benzyloxyphenyl)-4-oxobutyric acid methyl ester (169804-39-1) → 3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one (882041-72-7)

Guidance literature:

3,4,5-trimethoxy-benzaldehyde; 2-(benzo[1,3]dioxol-5-yl)-1-(4-benzyloxyphenyl)-4-oxobutyric acid methyl ester; With sodium methylate; In methanol; for 12h; Heating;

With acetic acid; In methanol; for 4h; Heating;

DOI:10.1016/j.bmc.2005.10.039

Reference yield: 39.0%

3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one (882041-72-7) → PD 169390 (313222-88-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; isopropyl alcohol; for 12h;

DOI:10.1016/j.bmc.2005.10.039

Reference yield:

3-benzo[1,3]dioxol-5-yl-5-(4-benzyloxy-phenyl)-5-hydroxy-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one (882041-72-7) → 3-benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-hydroxy-3-iodo-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / H₂ / Pd-C / ethanol; propan-2-ol / 12 h

2: 55 percent / ammonia; iodine / ethanol / 1 h / 20 °C

With ammonia; hydrogen; iodine; palladium on activated charcoal; In ethanol; isopropyl alcohol;

DOI:10.1016/j.bmc.2005.10.039

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

2-(benzo[1,3]dioxol-5-yl)-1-(4-benzyloxyphenyl)-4-oxobutyric acid methyl ester

Downstream raw materials:

PD 169390