His(DNP)-Pip-OMe*2HCl

Base Information

• Chemical Name: His(DNP)-Pip-OMe*2HCl
• CAS No.: 77910-16-8
• Molecular Formula: C₁₉H₂₂N₆O₇*2ClH
• Molecular Weight: 519.342
• Mol file: 77910-16-8.mol

Synonyms:His(DNP)-Pip-OMe*2HCl

Chemical Property of His(DNP)-Pip-OMe*2HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of His(DNP)-Pip-OMe*2HCl

There total 4 articles about His(DNP)-Pip-OMe*2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Boc-His(DNP)-Pip-OMe (77897-81-5) → His(DNP)-Pip-OMe*2HCl (77910-16-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃;

DOI:10.1021/jm00138a010

Reference yield:

(S)-methyl pipecolinate hydrochloride (18650-39-0) → His(DNP)-Pip-OMe*2HCl (77910-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NEt₃ / CH₂Cl₂ / 96 h / 25 °C

2: 98 percent / HCl / ethyl acetate / 0 °C

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1021/jm00138a010

Reference yield:

(2S)-2-piperidinecarboxylic acid L-tartrate (15912-30-8,35677-82-8,98626-57-4,109731-18-2,111478-73-0,112797-03-2,128684-94-6,138804-98-5) → His(DNP)-Pip-OMe*2HCl (77910-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 24 h / 25 °C

2: 87 percent / NEt₃ / CH₂Cl₂ / 96 h / 25 °C

3: 98 percent / HCl / ethyl acetate / 0 °C

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1021/jm00138a010

upstream raw materials:

Boc-His(DNP)-Pip-OMe

(S)-methyl pipecolinate hydrochloride

(2S)-2-piperidinecarboxylic acid L-tartrate

Boc-His(DNP)-ONSu

Downstream raw materials:

<*>Glu-His(DNP)-Pip-OMe

<*>Glu-His-Pip-OMe