2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

Base Information

Chemical Name:2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine
CAS No.:144881-86-7
Molecular Formula:C₁₇H₂₁ClN₂O₂
Molecular Weight:320.819
Hs Code.:

Synonyms:2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

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Chemical Property of 2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

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Technology Process of 2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

There total 8 articles about 2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 144881-81-2
2-benzyloxy-6-hydroxymethyl-3-isobutyl-5-methoxypyrazine

: 144881-86-7
2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; Ambient temperature;

Reference yield:

: 115978-65-9
5-chloro-3-isobutyl-6-methylpyrazine

: 144881-86-7
2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / 60percent aq. H₂O₂, maleic anhydride / CHCl₃ / Ambient temperature

2: 96 percent / methanol / 2 h / Heating

3: 62 percent / 1 h / Heating

4: 89 percent / 60percent aq. H₂O₂, maleic anhydride / CHCl₃ / Ambient temperature

5: 86 percent / 1 h / Heating

6: 97 percent / 10percent aq. K₂CO₃ / methanol / 0.5 h / Ambient temperature

7: 84 percent / NaOH, tetrabutylammonium bromide / CH₂Cl₂ / 3 h / Irradiation

8: 76 percent / Et₃N, MsCl / CH₂Cl₂ / Ambient temperature

With maleic anhydride; sodium hydroxide; tetrabutylammomium bromide; dihydrogen peroxide; potassium carbonate; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane; chloroform;

Reference yield:

: 144881-75-4
3-Chloro-5-isobutyl-2-methyl-pyrazine 1-oxide

: 144881-86-7
2-benzyloxy-6-chloromethyl-3-isobutyl-5-methoxypyrazine

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / methanol / 2 h / Heating

2: 62 percent / 1 h / Heating

3: 89 percent / 60percent aq. H₂O₂, maleic anhydride / CHCl₃ / Ambient temperature

4: 86 percent / 1 h / Heating

5: 97 percent / 10percent aq. K₂CO₃ / methanol / 0.5 h / Ambient temperature

6: 84 percent / NaOH, tetrabutylammonium bromide / CH₂Cl₂ / 3 h / Irradiation

7: 76 percent / Et₃N, MsCl / CH₂Cl₂ / Ambient temperature

With maleic anhydride; sodium hydroxide; tetrabutylammomium bromide; dihydrogen peroxide; potassium carbonate; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane; chloroform;