2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile

Base Information

• Chemical Name: 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile
• CAS No.: 106000-66-2
• Molecular Formula: C₂₄H₂₀N₄
• Molecular Weight: 364.45
• Mol file: 106000-66-2.mol

Synonyms:2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile

Chemical Property of 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile

There total 3 articles about 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-[1-(4-methylphenyl)ethylidene]malononitrile (3111-61-3) → 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile (106000-66-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Reflux;

DOI:10.1002/jhet.329

Reference yield: 82.0%

2-Amino-6-methyl-4,6-di-p-tolyl-cyclohexa-2,4-diene-1,1,3-tricarbonitrile (106000-62-8) → 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile (106000-66-2)

Guidance literature:

With piperidine; In methanol; for 0.166667h; Heating;

Reference yield:

para-methylacetophenone (122-00-9) + malononitrile (109-77-3) → 2-[3-cyano-4,6-bis-(4-methylphenyl)-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile (106000-66-2)

Guidance literature:

With hydrogenchloride; (Me₂NH)n*CO₂; Yield given. Multistep reaction; 1) 25 deg C, 1 h, 2) EtOH, 5 deg C;

DOI:10.1002/prac.19973390173

upstream raw materials:

2-Amino-6-methyl-4,6-di-p-tolyl-cyclohexa-2,4-diene-1,1,3-tricarbonitrile

para-methylacetophenone

malononitrile

2-[1-(4-methylphenyl)ethylidene]malononitrile

Downstream raw materials:

C₂₇H₂₇N₃O

C₂₆H₂₅N₃O

C₂₅H₂₃N₃O