2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Base Information

Chemical Name:2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole
CAS No.:88489-87-6
Molecular Formula:C₁₅H₁₂ClNO
Molecular Weight:257.719
Hs Code.:
DSSTox Substance ID:DTXSID80465870
Wikidata:Q82292150
Mol file:88489-87-6.mol

Synonyms:2-[4-(chloromethyl)phenyl]-5-methyl-1,3-benzoxazole;88489-87-6;SCHEMBL2997849;BENZOXAZOLE,2-[4-(CHLOROMETHYL)PHENYL]-5-METHYL-;DTXSID80465870;GISFVZAWWLPIJD-UHFFFAOYSA-N;AKOS005937521;4-(5-Methylbenzoxazol-2-Yl)benzyl Chloride;FT-0748825;A842624

Suppliers and Price of 2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(5-METHYL BENZOXAZOL-2-YL)BENZYL CHLORIDE 95.00%
5MG
$ 505.84

Total 7 raw suppliers

Chemical Property of 2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Chemical Property:

PSA：26.03000
LogP:4.54200
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:257.0607417
Heavy Atom Count:18
Complexity:278

Purity/Quality:

97% ^*data from raw suppliers

4-(5-METHYL BENZOXAZOL-2-YL)BENZYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)CCl

Technology Process of 2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

There total 3 articles about 2-[4-(Chloromethyl)phenyl]-5-methyl-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 4-(chloromethyl)-N-(2-hydroxy-5-methylphenyl)benzamide

: 88489-87-6
2-[4-(chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dichloro-benzene; at 175 ℃; for 3h;

Reference yield:

: 95-84-1
3-amino-4-hydroxytoluene

: 88489-87-6
2-[4-(chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 2-methoxy-ethanol / 4 h / 40 °C

2: toluene-4-sulfonic acid / 1,2-dichloro-benzene / 3 h / 175 °C

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In 2-methoxy-ethanol; 1,2-dichloro-benzene;

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 88489-87-6
2-[4-(chloromethyl)phenyl]-5-methyl-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 2-methoxy-ethanol / 4 h / 40 °C

2: toluene-4-sulfonic acid / 1,2-dichloro-benzene / 3 h / 175 °C

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In 2-methoxy-ethanol; 1,2-dichloro-benzene;