(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

Base Information

Chemical Name:(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester
CAS No.:143465-55-8
Molecular Formula:C₅₄H₈₈NO₁₃P
Molecular Weight:990.265
Hs Code.:

(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

Synonyms:(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

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Chemical Property of (R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

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Technology Process of (R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

There total 13 articles about (R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 143465-57-0
(R)-3-methoxymethyloxytetradecanoic acid

: 143465-54-7
Phosphoric acid (4aR,6S,7R,8R,8aR)-8-hydroxy-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-6-yl ester diphenyl ester

: 143465-55-8
(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1016/0040-4039(92)80009-9

Reference yield:

: (R)-3-Methoxymethoxy-tetradecanoic acid 2-oxo-2-phenyl-ethyl ester

: 143465-55-8
(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Zn dust / acetic acid

2: 92 percent / DCC / CH₂Cl₂

3: H₂ / 20percent Pd(OH)2 / tetrahydrofuran; methanol

4: 69 percent / CSA / dimethylformamide / Ambient temperature

5: 64 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; camphor-10-sulfonic acid; hydrogen; dicyclohexyl-carbodiimide; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(92)80009-9

Reference yield:

: 87357-65-1
(3R)-3-hydroxytetradecanoic acid phenacyl ester

: 143465-55-8
(R)-3-Methoxymethoxy-tetradecanoic acid (4aR,6S,7R,8R,8aR)-6-(diphenoxy-phosphoryloxy)-7-((R)-3-methoxymethoxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-benzo[1,3]dioxin-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylethylamine

2: Zn dust / acetic acid

3: 92 percent / DCC / CH₂Cl₂

4: H₂ / 20percent Pd(OH)2 / tetrahydrofuran; methanol

5: 69 percent / CSA / dimethylformamide / Ambient temperature

6: 64 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; camphor-10-sulfonic acid; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(92)80009-9