(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

Base Information

Chemical Name:(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one
CAS No.:143572-26-3
Molecular Formula:C₂₄H₂₈O₄Si
Molecular Weight:408.569
Hs Code.:

Synonyms:(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

Chemical Property:

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Technology Process of (3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

There total 6 articles about (3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39746-00-4,172821-93-1
(1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one

: 143572-26-3
(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / imidazole / dimethylformamide

2: 88 percent / NaOH / methanol

3: Bu₃P / tetrahydrofuran / Ambient temperature

4: 30percent H₂O₂

5: 1) KHMDS, 2) MoOPH / 1) THF, -78 deg C

With 1H-imidazole; sodium hydroxide; MoO₅*pyridine*HMPA; tributylphosphine; dihydrogen peroxide; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)92675-3

Reference yield:

: 84786-80-1
(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-[(tert-butyldiphenylsilyloxy)methyl]-2H-cyclopenta[b]furan-2-one

: 143572-26-3
(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Bu₃P / tetrahydrofuran / Ambient temperature

2: 30percent H₂O₂

3: 1) KHMDS, 2) MoOPH / 1) THF, -78 deg C

With MoO₅*pyridine*HMPA; tributylphosphine; dihydrogen peroxide; potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)92675-3

Reference yield:

: 130386-85-5
(3aR,4S,5R,6aS)-5-benzoyloxy-4-[(t-butyldiphenylsiloxy)methyl]hexahydro-2H-cyclopenta[b]furan-2-one

: 143572-26-3
(3aS,4S,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaOH / methanol

2: Bu₃P / tetrahydrofuran / Ambient temperature

3: 30percent H₂O₂

4: 1) KHMDS, 2) MoOPH / 1) THF, -78 deg C

With sodium hydroxide; MoO₅*pyridine*HMPA; tributylphosphine; dihydrogen peroxide; potassium hexamethylsilazane; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)92675-3