2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

Base Information

Chemical Name:2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid
CAS No.:428874-19-5
Molecular Formula:C₂₂H₂₅NO₇
Molecular Weight:415.443
Hs Code.:

2-benzyloxycarbonylamino-3-(3-<i>tert</i>-butoxycarbonyloxy-phenyl)-propionic acid

Synonyms:2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

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Chemical Property of 2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

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Technology Process of 2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

There total 3 articles about 2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: carbonic acid 3-bromomethyl-phenyl ester tert-butyl ester

: 428874-19-5
2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / sodium hexamethyldisilazide / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h

2: H₂ / palladium dichloride / tetrahydrofuran; ethanol / 18 h / 2585.81 Torr

3: 1.92 g / NaHCO₃; NaOH / dioxane; H₂O / 0.67 h / 0 - 20 °C

With sodium hydroxide; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;
DOI:10.1021/ja020091v

Reference yield:

: (3S,5S,6R)-3-(3-tert-Butoxycarbonyloxy-benzyl)-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 428874-19-5
2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / palladium dichloride / tetrahydrofuran; ethanol / 18 h / 2585.81 Torr

2: 1.92 g / NaHCO₃; NaOH / dioxane; H₂O / 0.67 h / 0 - 20 °C

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1021/ja020091v

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

: 428874-19-5
2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

Guidance literature:: With sodium hydroxide; sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 0.666667h;
DOI:10.1021/ja020091v