benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Base Information

Chemical Name:benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate
CAS No.:1575819-65-6
Molecular Formula:C₄₁H₄₇ClN₆O₄
Molecular Weight:723.315
Hs Code.:

benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Synonyms:benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

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Chemical Property of benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

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Technology Process of benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

There total 9 articles about benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575819-65-6
benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

4: zinc; ammonium chloride / methanol / 2 h / 50 °C

5: ethanol / 16 h / 20 °C / Inert atmosphere

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

7: dichloromethane / 16 h / 0 - 20 °C

8: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 760-58-7
2-cyano-4-methyl-pent-2-enoic acid

: 1575819-64-5
benzyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

: 1575819-65-6
benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 1575819-57-6
tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

: 1575819-65-6
benzyl (2-(4-chloro-benzamido)-1-((1-(2-cyano-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

3: zinc; ammonium chloride / methanol / 2 h / 50 °C

4: ethanol / 16 h / 20 °C / Inert atmosphere

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

6: dichloromethane / 16 h / 0 - 20 °C

7: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;