(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

Base Information

Chemical Name:(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester
CAS No.:103959-46-2
Molecular Formula:C₂₄H₃₇NO₃SSi
Molecular Weight:447.714
Hs Code.:

Synonyms:(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

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Technology Process of (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

There total 1 articles about (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 102614-13-1
2-phenyl-4(S)-<2-((2-methyl-2-propyl)thio)-2-oxoethyl>-2-oxazoline

: 107-02-8,25068-14-8
acrolein

: 103959-46-2
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1021/jo00369a047

Reference yield:

: 103959-46-2
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

: 103980-76-3
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃;
DOI:10.1021/jo00369a047

Reference yield:

: 103959-46-2
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-pent-4-enethioic acid S-tert-butyl ester

: 103959-49-5
(S)-4-{(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-allyl]-pent-4-enyl}-2-phenyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: Dibal / toluene / -78 °C

2: 2.) Et₃N / 1.) THF, 0 deg C, 2.) THF, CH₂Cl₂, 0 deg C

With diisobutylaluminium hydride; triethylamine; In toluene;
DOI:10.1021/jo00369a047