methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

Base Information

Chemical Name:methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate
CAS No.:203940-53-8
Molecular Formula:C₂₀H₂₁NO₆S
Molecular Weight:403.456
Hs Code.:

Synonyms:methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

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Chemical Property of methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

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Technology Process of methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

There total 6 articles about methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.2%

: 75-52-5
nitromethane

: 68348-23-2
3-(1,3-dioxolan-2-yl)benzaldehyde

: 102203-61-2
4-Methoxycarbonylphenylmethanethiol

: 203940-53-8
methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

Guidance literature:: With methylamine hydrochloride; potassium carbonate; In ethanol; at 60 ℃; for 5h;
DOI:10.1246/bcsj.20130261

Reference yield:

: 75-52-5
nitromethane

: C₁₄H₁₉NO₂

: 102203-61-2
4-Methoxycarbonylphenylmethanethiol

: 203940-53-8
methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

Guidance literature:: nitromethane; C₁₄H₁₉NO₂; With acetic acid; at 60 ℃; for 3h;

4-Methoxycarbonylphenylmethanethiol; at 60 - 80 ℃; for 16h;
DOI:10.1246/bcsj.20130261

Reference yield:

: 17789-14-9
3-(1,3-dioxolan-2-yl)-phenylbromide

: 203940-53-8
methyl 4-[({1-[3-(1,3-dioxolan-2-yl)phenyl]-2-nitroethyl}thio)methyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -58 °C

1.2: 1.5 h / -78 - -52 °C

2.1: benzene / 1 h / Reflux

3.1: acetic acid / 3 h / 60 °C

3.2: 16 h / 60 - 80 °C

With n-butyllithium; acetic acid; In tetrahydrofuran; hexane; benzene;
DOI:10.1246/bcsj.20130261