tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate

Base Information

• Chemical Name: tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate
• CAS No.: 1294437-88-9
• Molecular Formula: C₂₄H₂₇IN₂O₃
• Molecular Weight: 518.394
• Mol file: 1294437-88-9.mol

Synonyms:tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate

Chemical Property of tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate

There total 2 articles about tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl 2-(1-acetyl-1H-indol-3-yl)ethylbenzylcarbamate (1294437-85-6) → tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate (1294437-88-9)

Guidance literature:

tert-butyl 2-(1-acetyl-1H-indol-3-yl)ethylbenzylcarbamate; With mercury(II) trifluoroacetate; In dichloromethane; at 20 ℃; for 0.0833333h;

With iodine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201001669

Reference yield:

N-t-butyloxycarbonyl-N-(phenylmethyl)-1H-indole-3-ethanamine (371246-08-1) → tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate (1294437-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 20 °C

2.1: mercury(II) trifluoroacetate / dichloromethane / 0.08 h / 20 °C

2.2: 1 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; mercury(II) trifluoroacetate; sodium hydroxide; In dichloromethane;

DOI:10.1002/ejoc.201001669

Reference yield:

tert-butyl 2-(1-acetyl-2-iodo-1H-indol-3-yl)ethylbenzylcarbamate (1294437-88-9) → C19H19IN2O

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1002/ejoc.201001669

upstream raw materials:

tert-butyl 2-(1-acetyl-1H-indol-3-yl)ethylbenzylcarbamate

N-t-butyloxycarbonyl-N-(phenylmethyl)-1H-indole-3-ethanamine

Downstream raw materials:

(Z)-6-acetyl-3-benzyl-5-ethylidene-2,3,5,6-tetrahydroazocino[4,5-b]indol-4(1H)-one