BOC-L-BETA-HOMOSERINE(OBZL)

Base Information

• Chemical Name: BOC-L-BETA-HOMOSERINE(OBZL)
• CAS No.: 218943-31-8
• Molecular Formula: C16H23NO5
• Molecular Weight: 309.362
• Hs Code.: 2924299090
• Mol file: 218943-31-8.mol

Synonyms:(3R)-4-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]butanoic acid;Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(phenylmethoxy)-, (3R)-;

Chemical Property of BOC-L-BETA-HOMOSERINE(OBZL)

Chemical Property:

• Vapor Pressure: 4.85E-10mmHg at 25°C
• Refractive Index: 1.519
• Boiling Point: 480.5 °C at 760 mmHg
• PKA: 4.30±0.10(Predicted)
• Flash Point: 244.4 °C
• PSA: 84.86000
• Density: 1.154 g/cm³
• LogP: 2.96210
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-O-benzyl-L-beta-homoserine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Boc-o-benzyl-L-beta-homoserine

Technology Process of BOC-L-BETA-HOMOSERINE(OBZL)

There total 14 articles about BOC-L-BETA-HOMOSERINE(OBZL) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl N-[(1R)-1-(benzyloxymethyl)-3-diazenyl-2-oxo-propyl]carbamate → (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid (218943-31-8)

Guidance literature:

With silver(I) acetate; In tetrahydrofuran; water; at 40 ℃; for 5h;

Reference yield: 78.0%

tert-butyl N-{(1S)-[(benzyloxy)methyl]-3-diazo-2-oxopropyl}carbamate (193148-60-6) → (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid (218943-31-8)

Guidance literature:

With silver trifluoroacetate; triethylamine; In tetrahydrofuran; water; at -25 - 20 ℃; for 3h;

DOI:10.1002/1522-2675(20011017)84:10<2924::AID-HLCA2924>3.0.CO;2-E

Reference yield: 60.0%

(3R)-tert-butyloxycarbonyl-1-nitro-4-benzyloxybutane (1445444-24-5) → (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid (218943-31-8)

Guidance literature:

With acetic acid; sodium nitrite; In dimethyl sulfoxide; at 40 ℃; for 20h; Inert atmosphere;

DOI:10.1055/s-0032-1318344

upstream raw materials:

tert-butyl N-{(1S)-[(benzyloxy)methyl]-3-diazo-2-oxopropyl}carbamate

BOC-O-benzyl-L-serine

C₂₀H₂₉NO₇

N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol

Downstream raw materials:

(R)-6-(benzyloxymethyl)piperidine-2,4-dione

methyl (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoate