9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine

Base Information

• Chemical Name: 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine
• CAS No.: 85421-87-0
• Molecular Formula: C₃₂H₂₃N₇O₁₃S
• Molecular Weight: 745.64
• Mol file: 85421-87-0.mol

Synonyms:9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine

Chemical Property of 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine

There total 4 articles about 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-chloropurine (85421-90-5) → 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine (85421-87-0)

Guidance literature:

With thiourea; In ethanol; for 4h; Heating;

DOI:10.1021/jm00361a023

Reference yield:

6-chloro-9-trimethylsilylpurine (32865-86-4) → 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine (85421-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / mercuric cyanide, mercuric bromide, / 1,2-dichloro-ethane / Ambient temperature

2: 100 percent / thiourea / ethanol / 4 h / Heating

With mercury(II) cyanide; thiourea; mercury dibromide; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm00361a023

Reference yield:

6-deoxy-2,3,5-tris-O-(p-nitrobenzoyl)-D-allofuranosyl bromide (85505-01-7) → 9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-thiopurine (85421-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / mercuric cyanide, mercuric bromide, / 1,2-dichloro-ethane / Ambient temperature

2: 100 percent / thiourea / ethanol / 4 h / Heating

With mercury(II) cyanide; thiourea; mercury dibromide; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm00361a023

upstream raw materials:

9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-β-D-allofuranosyl>-6-chloropurine

6-chloro-9-trimethylsilylpurine

6-deoxy-2,3,5-tris-O-(p-nitrobenzoyl)-D-allofuranosyl bromide

6-chloropurine

Downstream raw materials:

9-(6'-deoxy-β-D-allofuranosyl)-6-thiopurine

Refernces