(Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide

Base Information

• Chemical Name: (Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide
• CAS No.: 1322684-98-9
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315
• Mol file: 1322684-98-9.mol

Synonyms:(Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide

Chemical Property of (Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide

There total 1 articles about (Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxybenzoylhydrazine (7466-54-8) + o-hydroxyacetophenone (118-93-4,104809-67-8) → (Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide (1322684-98-9)

Guidance literature:

In propan-1-ol; for 12h; Reflux;

DOI:10.1246/bcsj.20100340

Reference yield: 94.0%

(Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide (1322684-98-9) → 1-[2-(2-methoxybenzoyl)phenyl]ethanone (1322685-02-8)

Guidance literature:

With lead(IV) tetraacetate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1246/bcsj.20100340

Reference yield:

(Z)-N'-[1-(2-hydroxyphenyl)ethylidene]-2-methoxybenzohydrazide (1322684-98-9) → (MeOC6H4)C8H5NCHC8H4N(C6H4OMe) (1322685-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lead(IV) tetraacetate / tetrahydrofuran / 3 h / 20 °C

2: ammonium hydroxide; acetic acid / methanol / 48 h / 50 °C

With ammonium hydroxide; lead(IV) tetraacetate; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1246/bcsj.20100340

upstream raw materials:

2-methoxybenzoylhydrazine

o-hydroxyacetophenone

Downstream raw materials:

1-[2-(2-methoxybenzoyl)phenyl]ethanone

(MeOC₆H₄)C₈H₅NCHC₈H₄N(C₆H₄OMe)