AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

Base Information

• Chemical Name: AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2
• CAS No.: 1134206-53-3
• Molecular Formula: C₂₃H₃₃N₂OPS
• Molecular Weight: 416.568
• Mol file: 1134206-53-3.mol

Synonyms:AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

Chemical Property of AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

There total 6 articles about AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

BH3*AcSCH2P(C6H4-m-CH2CH2NMe2)2 (1134206-50-0) → AcSCH2P(C6H4-m-CH2CH2NMe2)2 (1134206-53-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 40 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.02.047

Reference yield:

2-(3-bromophenyl)ethan-1-ol (28229-69-8) → AcSCH2P(C6H4-m-CH2CH2NMe2)2 (1134206-53-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 - 23 °C

2.1: tetrahydrofuran / 30 h / 45 °C

3.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

3.2: 0 - 23 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

4.2: 0 - 23 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 23 °C / Inert atmosphere

6.1: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 4 h / 40 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; iodine; sodium hydride; diisobutylaluminium hydride; magnesium; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

2-(3-bromophenyl)-N,N-dimethylethanamine (774214-05-0) → AcSCH2P(C6H4-m-CH2CH2NMe2)2 (1134206-53-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

1.2: 0 - 23 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 - 23 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 23 °C / Inert atmosphere

4.1: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 4 h / 40 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; iodine; sodium hydride; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

BH₃*AcSCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

2-(3-bromophenyl)ethan-1-ol

2-(3-bromophenyl)ethyl methanesulfonate

2-(3-bromophenyl)-N,N-dimethylethanamine

Downstream raw materials:

AcGlySCH₂P(C₆H₄-m-CH₂CH₂NMe₂)2

AcGluSCH₂P(C₆H₄-m-CH₂NMe₂)2