1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

Base Information

Chemical Name:1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide
CAS No.:1610372-89-8
Molecular Formula:C₂₈H₃₀N₄O₇S
Molecular Weight:566.635
Hs Code.:

Synonyms:1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

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Chemical Property of 1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

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Technology Process of 1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

There total 10 articles about 1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1610372-81-0
5,7-dimethoxy-2-(6-(4-(methylsulfinyl)phenyl)-5-(2-(pyrrolidin-1-yl)ethoxy)pyridin-2-yl)quinazolin-4(3H)-one

: 1610372-89-8
1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

Guidance literature:: With ammonium hydroxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610372-89-8
1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 16 h / 120 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 5 °C

6.2: 2 h / 20 °C

7.1: sodium iodide / dimethyl sulfoxide / 4 h / 61 °C

8.1: 3-chloro-benzenecarboperoxoic acid; ammonium hydroxide / dichloromethane / 16 h / 0 - 20 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610372-89-8
1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 16 h / 120 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 5 °C

7.2: 2 h / 20 °C

8.1: sodium iodide / dimethyl sulfoxide / 4 h / 61 °C

9.1: 3-chloro-benzenecarboperoxoic acid; ammonium hydroxide / dichloromethane / 16 h / 0 - 20 °C

With ammonium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;