(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Base Information

• Chemical Name: (2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
• CAS No.: 1242175-38-7
• Molecular Formula: C₂₀H₁₈F₇NO₂
• Molecular Weight: 437.357
• Mol file: 1242175-38-7.mol

Synonyms:(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Chemical Property of (2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Chemical Property:

• Boiling Point: 387.9±42.0 °C(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

There total 1 articles about (2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H18F7NO2*ClH (171482-05-6) → (2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine (1242175-38-7)

Guidance literature:

C₂₀H₁₈F₇NO₂*ClH; With (R)-10-camphorsulfonic acid; In methanol; at 20 ℃;

In toluene; pH=9.5 - 10; optical yield given as %ee; Further stages; Alkaline aq. solution;

DOI:10.1080/00397910903221084

Reference yield: 99.2%

(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine (1242175-38-7) + 3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one (252742-72-6) → C23H21F7N4O3 (1242175-40-1,221350-96-5)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1080/00397910903221084

Reference yield:

(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine (1242175-38-7) → N(CH2CH2OH)C(CHO)C6H4FC(CH3)C6H3(CF3)2

Guidance literature:

(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine; With N-chloro-succinimide; potassium carbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1080/00397910903221084

upstream raw materials:

C₂₀H₁₈F₇NO₂*ClH

Downstream raw materials:

C₂₃H₂₁F₇N₄O₃