Colistin sulfate

Base Information

• Chemical Name: Colistin sulfate
• CAS No.: 1264-72-8
• Molecular Formula: 2(C52H98N16O13).5(H2SO4)
• Molecular Weight: 1253.51000
• Hs Code.: 29419000
• European Community (EC) Number: 213-907-3
• Wikipedia: Colistin
• Wikidata: Q73589871
• NCI Thesaurus Code: C65350
• RXCUI: 2709
• Metabolomics Workbench ID: 43094
• ChEMBL ID: CHEMBL499783
• Mol file: 1264-72-8.mol

Synonyms:NSC 248648;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;Belcomycin;Polymyxin E sulfate;Colomycin; Colomycin syrup;

Chemical Property of Colistin sulfate

Chemical Property:

• Appearance/Colour: Powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 200-220 °C
• Refractive Index: 1.575
• Boiling Point: 1537.3 °C at 760 mmHg
• Flash Point: 883.5 °C
• PSA: 573.64000
• Density: ==
• LogP: 1.96320
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Soluble in water
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 18
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 28
• Exact Mass: 1154.74992724
• Heavy Atom Count: 81
• Complexity: 2050

Purity/Quality:

98%min ^*data from raw suppliers

ColistinSulfate(MixtureofAandBcompound) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O
• Isomeric SMILES: CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
• Recent ClinicalTrials: IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
• Recent EU Clinical Trials: Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa
• Recent NIPH Clinical Trials: An evaluation of the efficacy and safety of colistimethate sodium injection in patients with multidrug-resistant Gram-negative bacterial infection - A multicenter, unblinded clinical study -
• Uses: antibacterial neuromuscular blocker Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B. [a]D= -65?(c= 1, Water) LOD: 3% Colistin sulfate A Polymyxin potent antibiotic and apoptosis inducer. This compound induces apoptosis through interaction with the cytoplasmic membrane. Colistin is a key microbiological component in Colistin Oxolinic Acid Blood Agar utilized in the cultivation of Aminobacter aminovorans, Bacillus species, Hyphomicrobium species and Methylobacterium species. It is also a critical component is VCN Inhibitor & VCNT Inhibitor growth media used in the isolation of Neisseria species.
• Clinical Use: Colistimethate sodium Infections due to Ps. aeruginosa and other Gram-negative rods resistant to less toxic agents Cystic fibrosis (inhalation therapy for pseudomonas infection) Polymyxin B and colistin sulfate Component of preparations for local application Superficial infections with Ps. aeruginosa and to prevent the colonization of burns Selective decontamination of the gut and as a paste for control of upper respiratory tract colonization in patients on prolonged mechanical ventilation (in combination with other agents)