{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

Base Information

Chemical Name:{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid
CAS No.:1451093-95-0
Molecular Formula:C₂₅H₁₉ClFNO₄S
Molecular Weight:483.948
Hs Code.:

Synonyms:{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

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Chemical Property of {6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

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Technology Process of {6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

There total 5 articles about {6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1451093-96-1
{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

: 1451093-95-0
{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: {6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=Ca. 2;

Reference yield:

: 1227385-03-6
7-chloro-3-hydroxymethyl-2-methyl-naphthalen-1-ol

: 1451093-95-0
{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

3.1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 20 °C

5.2: pH Ca_. 2

With tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1468-68-4
6-chloro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid

: 1451093-95-0
{6-chloro-4-[4-(4-fluoro-phenylsulfamoyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 60 °C

2.1: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

4.1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 20 °C

6.2: pH Ca_. 2

With tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;