Technology Process of 4-bromo-2-tolylthiazole
There total 2 articles about 4-bromo-2-tolylthiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromo-2-tolylthiazole;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1.16667h;
Inert atmosphere;
With
water;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1002/anie.201201265
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / chloroform / 18 h / 60 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
With
N-Bromosuccinimide; lithium diisopropyl amide;
In
tetrahydrofuran; chloroform;
DOI:10.1002/anie.201201265
- Guidance literature:
-
4-bromo-2-tolylthiazole;
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium acetate; bis(pinacol)diborane; XPhos;
In
1,4-dioxane;
at 110 ℃;
for 0.5h;
Inert atmosphere;
4-bromo-2-tolylthiazole;
With
potassium phosphate;
In
1,4-dioxane; water;
at 110 ℃;
for 14h;
Inert atmosphere;
DOI:10.1002/anie.201201265
