5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Base Information

Chemical Name:5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol
CAS No.:135426-27-6
Molecular Formula:C₂₁H₁₉F₂NO
Molecular Weight:339.385
Hs Code.:

Synonyms:5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Chemical Property:

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Technology Process of 5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

There total 6 articles about 5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 137586-51-7
5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester

: 135426-27-6
5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: With sodium hydroxide; LiAlH₄; SiO₂; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 450-95-3
2-fluoroacetophenone

: 135426-27-6
5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-27-6
5-Fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With piperidine; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1021/jm00113a019