{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
CAS No.:717138-75-5
Molecular Formula:C₂₇H₄₈N₆O₉
Molecular Weight:600.713
Hs Code.:

{[3,5-bis-(2-<i>tert</i>-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

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Chemical Property of {[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

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Technology Process of {[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

There total 1 articles about {[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3655-05-8
tert-butoxycarbonylglycine p-nitrophenylester

: 1,3,5-cis,cis-triamino-cyclohexane trihydrobromide

: 717138-75-5
{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Guidance literature:: cis,cis-1,3,5-triaminocyclohexane trihydrochloride; With sodium hydroxide; In water;

tert-butoxycarbonylglycine p-nitrophenylester; In N,N-dimethyl-formamide; benzene; at 45 ℃; for 18h;
DOI:10.1039/b403476g

Reference yield: 86.0%

: 717138-75-5
{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

: 2-amino-N-[3,5-bis-(2-amino-acetylamino)-cyclohexyl]-acetamide

Guidance literature:: {[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; for 18h;

With AG 1-X₈ Biorad anion exchange resin; hydroxide form; In water;
DOI:10.1039/b403476g

Reference yield:

: 717138-75-5
{[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

: N,N',N-tris(2-aminoethyl)cyclohexane-cis,cis-1,3,5-triamine*6HCl

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / dioxane / 18 h

1.2: 86 percent / AG 1-X₈ Biorad anion exchange resin, hydroxide form / H₂O

2.1: 69.3 percent / BH₃*THF / Heating

With hydrogenchloride; borane-THF; In 1,4-dioxane;
DOI:10.1039/b403476g