5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

Base Information

Chemical Name:5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>
CAS No.:193006-44-9
Molecular Formula:C₂₉H₂₈N₈O₄S
Molecular Weight:584.659
Hs Code.:

Synonyms:5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

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Chemical Property of 5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

Chemical Property:

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Technology Process of 5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

There total 5 articles about 5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 3-(3-cyano-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carbonyl chloride

: 193006-44-9
5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h; Yield given; Ambient temperature;
DOI:10.1021/jm980406a

Reference yield:

: 75-05-8,26809-02-9
acetonitrile

: 193006-43-8
3-(3-cyanophenyl)-5-(1H-tetrazol-1-ylmethyl)isoxazoline-5-carboxylic acid

: 193006-44-9
5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

Guidance literature:: With thionyl chloride; In toluene;

Reference yield:

: 64847-76-3
3-(hydroxyimino)methylbenzonitrile

: 193006-44-9
5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<<5-<2'-(tertbutylaminosulfonyl)<1,1'-biphenyl>-4-yl>-4,5-dihydro-5-(1H-tetrazol-1-ylmethyl)->>

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) K₂CO₃, 2.) bleach / 1.) DMF, RT, 12 h, 2.) THF, RT, 3 h

2: 0.5 M aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature

3: SOCl₂ / acetonitrile / 1 h / Heating

4: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With lithium hydroxide; sodium hypochlorite; thionyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm980406a