2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

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Chemical Name:2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol
CAS No.:1428866-54-9
Molecular Formula:C₂₅H₃₆N₂O₇
Molecular Weight:476.57
Hs Code.:

Synonyms:2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

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Chemical Property of 2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

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Technology Process of 2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

There total 6 articles about 2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1428866-52-7
2-benzyloxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

: 1428866-54-9
2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 2327.23 Torr;
DOI:10.1021/jm4001693

Reference yield:

: 3413-15-8
(S)-3-n-butylphthalide

: 1428866-54-9
2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; methanol / 0.5 h / 50 °C

1.2: -10 - 0 °C

2.1: dmap; triethylamine / dichloromethane / 5 h / -10 °C

2.2: 1 h / 20 °C / pH 2

3.1: potassium carbonate / acetone / 8 h / 20 °C

4.1: dmap / dichloromethane / 0.17 h / 0 °C

4.2: 8 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / 2327.23 Torr

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jm4001693

Reference yield:

: (-)-2-(1-hydroxypentyl)benzoic acid

: 1428866-54-9
2-hydroxy-5-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 5 h / -10 °C

1.2: 1 h / 20 °C / pH 2

2.1: potassium carbonate / acetone / 8 h / 20 °C

3.1: dmap / dichloromethane / 0.17 h / 0 °C

3.2: 8 h / 20 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / 2327.23 Torr

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; acetone;
DOI:10.1021/jm4001693