Technology Process of (3S,4S,4aS,8aS)-4-[(3-hydroxy-5-methylphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalene-2-carboxylic acid
There total 6 articles about (3S,4S,4aS,8aS)-4-[(3-hydroxy-5-methylphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalene-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3S,4S,4aS,8aS)-4-[(3-methoxy-5-methylphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalene-2-carboxylicacid;
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
for 4h;
Inert atmosphere;
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 85 ℃;
for 0.75h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridinium chlorochromate / dichloromethane / 2 h / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
2.2: 1.75 h / 0 - 20 °C
3.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / Reflux
4.1: dihydrogen peroxide; sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 27 h / 20 °C
5.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere
5.2: 0.75 h / 85 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; potassium tert-butylate; dihydrogen peroxide; boron tribromide; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
1.2: 1.75 h / 0 - 20 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / Reflux
3.1: dihydrogen peroxide; sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 27 h / 20 °C
4.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere
4.2: 0.75 h / 85 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; potassium tert-butylate; dihydrogen peroxide; boron tribromide;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
![(3S,4S,4aS,8aS)-4-[(3-methoxy-5-methylphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalene-2-carboxylicacid](/Databaselist/images/loading.webp)
