C₃₆H₄₈O₇

Base Information

Chemical Name:C₃₆H₄₈O₇
CAS No.:162062-39-7
Molecular Formula:C₃₆H₄₈O₇
Molecular Weight:592.773
Hs Code.:

C<sub>36</sub>H<sub>48</sub>O<sub>7</sub>

Synonyms:C₃₆H₄₈O₇

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Chemical Property of C₃₆H₄₈O₇

Chemical Property:

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Technology Process of C₃₆H₄₈O₇

There total 14 articles about C₃₆H₄₈O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131311-17-6
[(2R,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-methanol

: 162062-39-7
C₃₆H₄₈O₇

Guidance literature:: Multi-step reaction with 14 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

2: 1.) NaHMDS / 1.) THF, 0 deg C, 10 min, 2.) 0.5 h

3: 100 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethyl acetate / 12 h / 25 °C

4: 97 percent / CSA / CH₂Cl₂; methanol / 1 h / 0 °C

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

6: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 25 °C

7: 91 percent / TBAF / tetrahydrofuran / 8 h / 65 °C

8: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

9: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

10: 1.) t-BuLi, 2.) (2-thiophene)Cu(CN)Li, HMPA

11: 100 percent / PPTS / 1,2-dimethoxy-ethane; H₂O / 25 °C

12: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) 0 deg C

13: 82 percent / LiOH / 1,2-dimethoxy-ethane; H₂O / 25 °C

14: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; tert.-butyl lithium; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; sodium carbonate; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ja00108a051

Reference yield:

: 131311-18-7
(2S,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-carbaldehyde

: 162062-39-7
C₃₆H₄₈O₇

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) NaHMDS / 1.) THF, 0 deg C, 10 min, 2.) 0.5 h

2: 100 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethyl acetate / 12 h / 25 °C

3: 97 percent / CSA / CH₂Cl₂; methanol / 1 h / 0 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

5: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 25 °C

6: 91 percent / TBAF / tetrahydrofuran / 8 h / 65 °C

7: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

8: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

9: 1.) t-BuLi, 2.) (2-thiophene)Cu(CN)Li, HMPA

10: 100 percent / PPTS / 1,2-dimethoxy-ethane; H₂O / 25 °C

11: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) 0 deg C

12: 82 percent / LiOH / 1,2-dimethoxy-ethane; H₂O / 25 °C

13: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; tert.-butyl lithium; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; sodium carbonate; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ja00108a051

Reference yield:

: 161984-56-1
(2S,3R,4aS,6R,7S,8aR)-3-Benzyloxy-2-(2-benzyloxy-ethyl)-7-(tert-butyl-dimethyl-silanyloxy)-6-[(Z)-4-(tert-butyl-dimethyl-silanyloxy)-but-1-enyl]-2,4a,6-trimethyl-octahydro-pyrano[3,2-b]pyran

: 162062-39-7
C₃₆H₄₈O₇

Guidance literature:: Multi-step reaction with 12 steps

1: 100 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethyl acetate / 12 h / 25 °C

2: 97 percent / CSA / CH₂Cl₂; methanol / 1 h / 0 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

4: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 25 °C

5: 91 percent / TBAF / tetrahydrofuran / 8 h / 65 °C

6: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

7: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

8: 1.) t-BuLi, 2.) (2-thiophene)Cu(CN)Li, HMPA

9: 100 percent / PPTS / 1,2-dimethoxy-ethane; H₂O / 25 °C

10: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) 0 deg C

11: 82 percent / LiOH / 1,2-dimethoxy-ethane; H₂O / 25 °C

12: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium carbonate; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ja00108a051