Technology Process of 5-(6-aminohexyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione
There total 1 articles about 5-(6-aminohexyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere
1.2: 3.5 h / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: hydrogen; 20% palladium hydroxide on charcoal / methanol / 17 h / 20 °C
4.1: pyridine / chloroform / 0 - 20 °C / Inert atmosphere
5.1: sodium azide / N,N-dimethyl-formamide / 4 h / 20 - 50 °C / Inert atmosphere
6.1: hydrogen; 20% palladium hydroxide on charcoal / tetrahydrofuran / 6 h / 20 °C
With
pyridine; sodium azide; 20% palladium hydroxide on charcoal; hydrogen; sodium hydride;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c2cc38443d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / water
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5.5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; N-ethyl-N,N-diisopropylamine;
In
water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc38443d
