N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide

Base Information

• Chemical Name: N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide
• CAS No.: 1197420-46-4
• Molecular Formula: C₁₇H₁₁BrF₄N₂O₃
• Molecular Weight: 447.184
• Mol file: 1197420-46-4.mol

Synonyms:N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide

Chemical Property of N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide

There total 1 articles about N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{[6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide (1141877-97-5) → N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide (1197420-46-4)

Guidance literature:

With AD-H column; In hexane; isopropyl alcohol; Resolution of racemate;

DOI:10.1021/jm900915x

Reference yield:

[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]boronic acid (1105511-68-9) + N-{[(4S)-6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide (1197420-46-4) → 4-fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide (1141877-98-6)

Guidance literature:

With potassium phosphate trihydrate; In water; N,N-dimethyl-formamide; at 20 - 120 ℃; Microwave irradiation;

DOI:10.1021/jm900915x

upstream raw materials:

N-{[6-bromo-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide

Downstream raw materials:

4-fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide