Technology Process of tert-butyl 2-fluoro-4-benzoate
There total 5 articles about tert-butyl 2-fluoro-4-benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; methanesulfonyl chloride;
1.) 2-4 deg C, 20 min, 2.) 80 deg C, 15 min;
DOI:10.1021/jm00041a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / SOCl2 / toluene / 3 h / Heating
2: 1.) BuLi / 1.) hexane, 20 deg C, 20 min, 2.) hexane, THF, 22 h
3: 93 percent / ammonium formate / 10percent Pd/C / ethanol / 0.83 h
4: 76 percent / HOAc / 48 h / Ambient temperature
5: 57 percent / CH3SO2Cl, pyridine / 1.) 2-4 deg C, 20 min, 2.) 80 deg C, 15 min
With
pyridine; n-butyllithium; thionyl chloride; ammonium formate; acetic acid; methanesulfonyl chloride;
palladium on activated charcoal;
In
ethanol; toluene;
DOI:10.1021/jm00041a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BuLi / 1.) hexane, 20 deg C, 20 min, 2.) hexane, THF, 22 h
2: 93 percent / ammonium formate / 10percent Pd/C / ethanol / 0.83 h
3: 76 percent / HOAc / 48 h / Ambient temperature
4: 57 percent / CH3SO2Cl, pyridine / 1.) 2-4 deg C, 20 min, 2.) 80 deg C, 15 min
With
pyridine; n-butyllithium; ammonium formate; acetic acid; methanesulfonyl chloride;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00041a015
