tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1589535-05-6
Molecular Formula:C₂₄H₃₀N₄O₆S₂
Molecular Weight:534.657
Hs Code.:

Synonyms:tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 9 articles about tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361224-49-8
benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate

: 1589535-05-6
tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 2.17 h / 20 °C

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium t-butanolate / 1,4-dioxane / 80 - 100 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 20 °C

5.1: triethylamine / dichloromethane / 0.08 h / 20 °C

5.2: 20 °C

With trifluorormethanesulfonic acid; palladium diacetate; sodium tris(acetoxy)borohydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5000497

Reference yield:

: 1589535-03-4
benzyl 4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1589535-05-6
tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 20 °C

2.1: triethylamine / dichloromethane / 0.08 h / 20 °C

2.2: 20 °C

With trifluorormethanesulfonic acid; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm5000497

Reference yield:

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1589535-05-6
tert-butyl (5-((4-(4-(methylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium t-butanolate / 1,4-dioxane / 80 - 100 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 20 °C

3.1: triethylamine / dichloromethane / 0.08 h / 20 °C

3.2: 20 °C

With trifluorormethanesulfonic acid; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5000497