diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

Base Information

Chemical Name:diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate
CAS No.:1339075-36-3
Molecular Formula:C₂₆H₃₂NO₅PS
Molecular Weight:501.584
Hs Code.:

Synonyms:diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

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Chemical Property of diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

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Technology Process of diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

There total 8 articles about diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6165-69-1
Thien-3-ylboronic acid

: 1339075-26-1
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-bromophenyl)-propyl)phosphonate

: 1339075-36-3
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 120 ℃; for 0.5h; Microwave irradiation; Sealed tube;
DOI:10.1021/jo201715x

Reference yield:

: 1339075-20-5
diethyl (1-(4-bromophenyl)-3-oxopropyl)phosphonate

: 1339075-36-3
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / ethanol / 5 h

2.1: sodium cyanoborohydride / methanol / 20 °C

2.2: 0 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 1.5 h

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium cyanoborohydride; sodium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 4.1: Suzuki coupling;
DOI:10.1021/jo201715x

Reference yield:

: C₂₀H₂₇BrNO₄P

: 1339075-36-3
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-(thiophen-3-yl)-phenyl)propyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.5 h

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jo201715x