diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Base Information

Chemical Name:diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride
CAS No.:1393737-32-0
Molecular Formula:C₂₂H₂₅Cl₂NO₄*ClH
Molecular Weight:474.812
Hs Code.:

Synonyms:diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Chemical Property:

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Technology Process of diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

There total 1 articles about diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393737-34-2
diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate

: 1393737-32-0
diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether;
DOI:10.1016/j.tet.2012.06.090

Reference yield: 89.0%

: 1393737-32-0
diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

: 1393737-34-2
diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate

Guidance literature:: With sodium hydrogencarbonate; In water;
DOI:10.1016/j.tet.2012.06.090

Reference yield:

: 1393737-32-0
diethyl (S)-2-(3,4-dichlorobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

: 1393737-48-8
(R)-4-(3,4-dichlorobenzyl)-4-hydroxymethyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: acetonitrile / 15 h / 20 °C

4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sodium hydrogencarbonate; methoxybenzene; In diethyl ether; nitromethane; water; acetonitrile;
DOI:10.1016/j.tet.2012.06.090