N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

Base Information

Chemical Name:N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester
CAS No.:131791-80-5
Molecular Formula:C₃₁H₃₉BrN₄O₇
Molecular Weight:659.577
Hs Code.:

Synonyms:N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

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Chemical Property of N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

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Technology Process of N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

There total 12 articles about N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 131791-79-2
(2,R,5S)-5-(tert-butoxycarbonylamino)-3-methyl-2-<(2-bromo-1H-indol-3-yl)methyl>-4-oxo-3-azahexanoic acid

: 134781-82-1
(R)-β-Tyrosine Methyl Ether Methyl Ester hydrochloride

: 131791-80-5
N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo00017a037

Reference yield: 84.0%

: 131791-82-7,227319-36-0
methyl (-)-(3R)-3-amino-3-(4-methoxyphenyl)propanoate

: 131791-79-2
(2,R,5S)-5-(tert-butoxycarbonylamino)-3-methyl-2-<(2-bromo-1H-indol-3-yl)methyl>-4-oxo-3-azahexanoic acid

: 131791-80-5
N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

Guidance literature:: With dicyclohexyl-carbodiimide;
DOI:10.1021/jo00004a005

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 131791-80-5
N-Boc-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / DCC/HOBt / tetrahydrofuran / 24 h / 4 °C

2: 78 percent / benzoyl peroxide, N-bromosuccinimide / CH₂Cl₂ / 0.5 h / 0 °C

3: 99 percent / Na₂CO₃ / methanol; H₂O / 1 h / 70 °C

4: 84 percent / triethylamine, DCC / tetrahydrofuran / Ambient temperature

With N-Bromosuccinimide; sodium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00017a037