4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Base Information

Chemical Name:4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide
CAS No.:1618658-88-0
Molecular Formula:C₂₈H₂₈N₆O₄
Molecular Weight:512.568
Hs Code.:

Synonyms:4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Suppliers and Price of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CC-671
10mg
$ 1050.00

DC Chemicals
CC-671 >98%
100 mg
$ 650.00

ChemScene
CC-671 98.86%
10mg
$ 1068.00

ChemScene
CC-671 98.86%
5mg
$ 708.00

ChemScene
CC-671 98.86%
50mg
$ 3468.00

ChemScene
CC-671 98.86%
100mg
$ 4668.00

ChemScene
CC-671 98.86%
1mg
$ 228.00

Cayman Chemical
CC-671
10mg
$ 200.00

Cayman Chemical
CC-671
5mg
$ 113.00

Cayman Chemical
CC-671
1mg
$ 25.00

Total 6 raw suppliers

Chemical Property of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

CC-671 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses CC-671, is a novel dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) inhibitor for the treatment of triple negative breast cancer initiated from a phenotypic screen.

Technology Process of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

There total 8 articles about 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1618663-23-2
4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

: 1618658-88-0
4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Guidance literature:: 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With ammonia; In methanol;

With ammonium hydroxide; In water; at 20 - 50 ℃;
DOI:10.1021/acs.jmedchem.7b01223

Reference yield: 44.0%

: 1618658-88-0
4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1012785-51-1
2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 1618658-88-0
4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / water; mineral oil; N,N-dimethyl-formamide / 3 h / 0 - 22 °C / Inert atmosphere

2.1: sodium t-butanolate / 1,4-dioxane / 16 h

3.1: water; 1,4-dioxane / 15 h / 75 °C / Alkaline conditions

4.1: 1,4-dioxane / 1.5 h / Alkaline conditions; Inert atmosphere; Sealed tube; Heating

5.1: trifluoroacetic acid / dichloromethane / 20 °C

5.3: 20 - 50 °C

With sodium hydride; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling / 4.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/acs.jmedchem.7b01223