(5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane

Base Information

• Chemical Name: (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane
• CAS No.: 1026837-87-5
• Molecular Formula: C₂₁H₃₀O₂S
• Molecular Weight: 346.534
• Mol file: 1026837-87-5.mol

Synonyms:(5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane

Chemical Property of (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane

There total 4 articles about (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5S)-5-isopropyl-2-methylene-1-phenylsulfonylcyclohexane + 1-iodo-4-pentene (7766-48-5) → (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane (1026837-87-5)

Guidance literature:

(5S)-5-isopropyl-2-methylene-1-phenylsulfonylcyclohexane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

1-iodo-4-pentene; In tetrahydrofuran; hexane; at -78 - -30 ℃; for 4h;

DOI:10.1021/ol051049i

Reference yield:

(-)-perillyl alcohol (536-59-4,18457-55-1) → (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane (1026837-87-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 96 percent / H₂ / PtO₂

2.1: 89 percent / Et₃N / benzene / 0.25 h / 20 °C

3.1: 86 percent / m-CPBA / diethyl ether / 1 h / -20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 89 percent / tetrahydrofuran; hexane / 4 h / -78 - -30 °C

With n-butyllithium; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; hexane; benzene;

DOI:10.1021/ol051049i

Reference yield:

((S)-5-Isopropyl-2-methylene-cyclohexanesulfinyl)-benzene (1027081-47-5) → (5S)-5-isopropyl-2-methylene-1-(4-pentenyl)-1-phenylsulfonylcyclohexane (1026837-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 86 percent / m-CPBA / diethyl ether / 1 h / -20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 89 percent / tetrahydrofuran; hexane / 4 h / -78 - -30 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ol051049i

upstream raw materials:

1-iodo-4-pentene

((S)-5-Isopropyl-2-methylene-cyclohexanesulfinyl)-benzene

(-)-perillyl alcohol

dihydroperilla alcohol