4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

Base Information

Chemical Name:4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide
CAS No.:1381925-30-9
Molecular Formula:C₂₀H₁₈F₄N₂O₃
Molecular Weight:410.368
Hs Code.:

Synonyms:4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

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Chemical Property of 4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

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Technology Process of 4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

There total 5 articles about 4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 473721-14-1
2-[4-fluoro-3-(trifluoromethyl)phenyl]acetyl chloride

: 1381925-32-1
4-amino-2-(2-methoxy-1-methyl-ethyl)-2,3-dihydro-isoindol-1-one

: 1381925-30-9
4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield:

: 98475-07-1
2-bromomethyl-3-nitro-benzoic acid methyl ester

: 1381925-30-9
4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 1.5 h / Reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 0.75 h / 20 °C / 2585.81 Torr

3: sodium hydrogencarbonate / water; tetrahydrofuran / 1.5 h / 20 °C

With hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 59382-59-1
2-methyl-3-nitro-benzoic acid methyl ester

: 1381925-30-9
4-fluoro-N-[2-(2-methoxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

2: toluene / 1.5 h / Reflux

3: hydrogen / palladium 10% on activated carbon / methanol / 0.75 h / 20 °C / 2585.81 Torr

4: sodium hydrogencarbonate / water; tetrahydrofuran / 1.5 h / 20 °C

With N-Bromosuccinimide; hydrogen; sodium hydrogencarbonate; dibenzoyl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; water; toluene;