4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride

Base Information

• Chemical Name: 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride
• CAS No.: 925427-31-2
• Molecular Formula: C₁₄H₁₀ClN₃O₃*ClH
• Molecular Weight: 340.166
• Mol file: 925427-31-2.mol

Synonyms:4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride

Chemical Property of 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride

There total 6 articles about 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate (925427-24-3) + 3-monochlorophenol (108-43-0) → 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride (925427-31-2)

Guidance literature:

3-monochlorophenol; With sodium hydride; In 1,4-dioxane;

ethyl 4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate; In 1,4-dioxane; at 180 ℃; for 10h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; water; pH=1;

Reference yield:

C14H10ClN3O3 (925546-62-9) → 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride (925427-31-2)

Guidance literature:

With hydrogenchloride; In water; pH=1;

Reference yield:

ethyl 6-chloro-4-(methylamino)-5-nitro-3-pyridinecarboxylate (925427-22-1) → 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride (925427-31-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / nickel / ethanol / 23 h / 20 °C

2: 1 - 3 h / Heating / reflux

3: sodium hydride / 1,4-dioxane / 10 h / 180 °C / Microwave

4: hydrogenchloride / water / pH 1

With hydrogenchloride; hydrogen; sodium hydride; nickel; In 1,4-dioxane; ethanol; water;

upstream raw materials:

ethyl 4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate

C₁₄H₁₀ClN₃O₃

3-monochlorophenol

ethyl 6-chloro-4-(methylamino)-5-nitro-3-pyridinecarboxylate

Downstream raw materials:

4-[(3-chlorophenyl)oxy]-1-methyl-7-(1-piperidinylcarbonyl)-1H-imidazo[4,5-c]pyridine