6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Base Information

Chemical Name:6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide
CAS No.:442549-57-7
Molecular Formula:C₃₃H₄₇N₅O₅Si
Molecular Weight:621.852
Hs Code.:

Synonyms:6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Suppliers and Price of 6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

There total 7 articles about 6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4318-37-0
1-Methylhomopiperazine

Pd₂ (dba)2: Pd₂ (dba)2

: 8-bromo-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-quinoline-2-carboxylic acid

: 442549-57-7
6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Guidance literature:: In dichloromethane; caesium carbonate; toluene;

Reference yield: 81.0%

: 4318-37-0
1-Methylhomopiperazine

: 442549-56-6
8-bromo-6-methoxy-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

: 442549-57-7
6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Guidance literature:: With 4 A molecular sieve; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; for 17h; Heating;
DOI:10.1016/j.bmc.2006.10.037

Reference yield:

: 442549-54-4
8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid

: 442549-57-7
6-methoxy-8-(4-methyl-[1,4]diazepan-1-yl)-4-(2-trimethylsilanylethoxymethoxy)quinoline-2-carboxylic acid [4-(morpholin-4-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 1-hydroxybenzotriazole; ethyldiisopropylamine / dimethylformamide / 16 h / 20 °C

2: 80 percent / NaH / 1-methyl-pyrrolidin-2-one / 4.5 h / 20 °C

3: 81 percent / molecular sieves 4 Angstroem; rac-BINAP; Cs₂CO₃ / Pd₂(dba)3 / toluene / 17 h / Heating

With 4 A molecular sieve; sodium hydride; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; toluene; 3: Buchwald-Hartwig coupling;
DOI:10.1016/j.bmc.2006.10.037